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Sphingolipids are crucial in the sorting of proteins in growing nerve cells

22.02.2019

A genetically-induced disorder in the formation of fats - so-called sphingolipids -, an important component of cell membranes, leads to neuronal degeneration in the human nervous system.

How these support the development and function of nerve cells is poorly understood so far. Thomas Hummel and his colleagues from the Department of Neurobiology have now shown that sphingolipids are crucial in the sorting of proteins in growing nerve cells. The results of their study recently appeared in the prestigious journal Nature Communications.

Publication in Nature Communications "Sphingolipid-dependent Dscam sorting regulates axon segregation" by Gaurav Goyal, Junfeng Zheng, Elisabeth Adam, Georg Steffes, Mamta Jain, Kristaps Klavins & Thomas Hummel DOI: 10.1038/s41467-019-08765-2

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